The manual has been prepared keeping the difficulties of the postgraduate students in medicine, who have to prepare for their examinations in a time-bound schedule and cover a very large area of the subject. The manual addresses to the point-wise description of the common diseases as well as approach to the systems. It presents many clinical pictures, tables and flowcharts which are very informative and easily memorable, and a large volume of essential, crucial as well as indispensable material of medicine has been given. The manual aims to serve as a textbook for undergraduate and as a handy guide for the postgraduate students (MD/DNB) and as an essential clinic-table reference for all the practising physicians.