Andhra Pradesh, one of the 29 states of India, has been explored intensively by the senior author and his research scholars for plant wealth during the last 35 years. Bentham and Hooker’s system of classification has been followed in the enumeration of families with certain exceptions to accommodate recent changes. A dichotomous indented key has been given for families, genera and species. A total of 2880 species spread over 1112 genera and 177 families have been enumerated. Under each family key to the genera followed by the genus with its authority, key to the species, followed by species enumeration is given. The enumeration of species included the complete citation according to ICN, basionym if any, synonyms to connect to Flora of British India and Flora of Presidency of Madras. It is followed by detailed description, distribution in the state, flowering and fruiting period, vernacular names and specimens examined. References, Index to families, genera and species are given at the end.